INTERNATIONAL CONGRESS OF
PharmacoGenetics
Nutrigenomics and Pharmacogenetics: The Interplay Between Diet and Drug Metabolism
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Mina Shirmohammadpour,1 Arman Taran,2 Bahman Mirzaei,3,*
1. Department of Microbiology and Virology, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
2. Department of Microbiology and Virology, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
3. Department of Microbiology and Virology, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
- Introduction: Diet significantly affects the pharmacokinetics and pharmacodynamics of many drugs. Recent advances in pharmacogenetics reveal that genetic variations in drug-metabolizing enzymes may interact with nutritional factors, influencing therapeutic efficacy and toxicity. This review examines the bidirectional relationship between nutrition and pharmacogenomics, emphasizing the role of diet in modulating gene expression and drug metabolism.
- Methods: A narrative review of relevant literature from 2015 to 2024 was conducted across PubMed and Web of Science. Studies addressing the impact of micronutrients, dietary patterns, and bioactive compounds on cytochrome P450 enzyme activity and drug response were included.
- Results: Certain nutrients, such as folate, polyphenols, and omega-3 fatty acids, modulate the activity of drug-metabolizing enzymes like CYP2D6 and CYP3A4. Genetic polymorphisms (e.g., in NAT2, TPMT, UGT1A1) influence nutrient–drug interactions and therapeutic outcomes. Personalized nutrition based on genetic profiles may enhance drug efficacy and minimize adverse effects.
- Conclusion: Nutritional status is a critical but often overlooked factor in pharmacogenomic variability. Integrating dietary assessment into personalized medicine can optimize drug therapy and promote precision healthcare.
- Keywords: Nutrition, Pharmacogenomics, Drug metabolism, Nutrigenomics, CYP enzymes, Personalized medicine
