INTERNATIONAL CONGRESS OF
PharmacoGenetics
Nanotechnology-enabled pharmacogenomics: a revolution in cancer drug development
-
Fatemeh Davodabadi ,1,*
1. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.
- Introduction: The combination of pharmacogenomics and nanotechnology has created a highly advanced field of personalized medicine known as nano-enabled pharmacogenomics. There is a particular emphasis on how nanotechnology helps avoid the problems associated with pharmacogenomics earlier, such as drug resistance and targeted delivery.
- Methods: This is an overview study. The keywords “Nanotechnology”, “Pharmacogenomics”, and “Cancer” were used for Science databases the search in PubMed, Scopus, Google Scholar, and Web of for studies published.
- Results: There are multiple points at which nanotechnology and personalized medicine intersect: 1) Nanotechnology has a lot to offer in the diagnostic field, including exploring drug targets, pharmacogenetic testing, and in vitro and in vivo testing. To provide an accurate diagnosis of specific targets/genes, nanomaterials such as metal nanoparticles (NPs) (gold, silver and iron NPs), dendrimers, liposomes, quantum dots, and carbon nanotubes have been explored. 2) It has a high therapeutic potential since nanomedicine targets a specific target to treat a specific disease in a specific patient, and it can be used to treat a wide range of diseases. 3) As a result of nanomedicine's targeting capabilities, nanomedicine can achieve much higher doses than non-formulated drugs, which allows tailored doses based on the particular patient's condition. 4) Nanomedicine can circumvent two major factors determining individualized drug response: cytochrome-P enzyme variability and drug transporters.
- Conclusion: In personalized medicine, nanomedicine can increase the bioavailability and compatibility of drugs, and allow them to be delivered to the right patients, at the right time, with the best efficacy. It can also be a valuable contribution to the understanding of the genome of an individual, as well as to the development of diagnostic and therapeutic methods. Patients' genetic profiles can be used to customize nanomedicines for multiple cancers.
- Keywords: Nanotechnology, Cancer, Treatment, Pharmacogenomics, Diagnosis
