INTERNATIONAL CONGRESS OF
PharmacoGenetics
Challenges in Nanomedicine and Personalized Medicine
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Fatemeh Davodabadi ,1,*
1. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.
- Introduction: Nanomedicine and personalized medicine are both new to medical practice. As nanotechnology advances in medicine, nanomedicine is incorporated into diagnostic and therapeutic tools to manage a variety of medical conditions. In contrast, personalized medicine, or precision medicine, is a concept aimed at individualizing/customizing therapeutic management based on the patient's personal characteristics. In recent years, researchers have been using nanotechnology in personalized medicine to combine different aspects.
- Methods: This is an overview study. The keywords “Nanotechnology”, “Personalized Medicine”, and “Challenges” were used for Science databases the search in PubMed, Scopus, Google Scholar, and Web of for studies published.
- Results: In order for nanomedicine to be translated into personalized medicines, it is essential that large-scale synthesis with high reproducibility be done. In the laboratory or for preclinical and clinical studies, these drug-loaded nanocarriers are usually synthesized in small batches, depending on the number of studies that will be conducted. The large-scale manufacturing of nanoparticles, on the other hand, seems to be more challenging, due to the complexity of the different types of nanoparticles, that can cause even the slightest change in the manufacturing process to have a huge impact on their properties. There are often a number of steps necessary to scale up these nanomedicines, not only in terms of manufacturing, but also in terms of preclinical and clinical studies, thus making it difficult to scale up a new nanomedicine. New nanomedicines can be challenging to gain regulatory approval, especially if products with similar efficacy already exist for the same indication. Researchers are therefore working to improve conventional drugs' biodistribution, bioavailability, and efficacy.
- Conclusion: It is imperative to address the manufacturing challenges associated with nanomedicines in order for them to be developed for personalized medicine.
- Keywords: Nanotechnology, Personalized Medicine, Challenges
