کتابچه الکترونیکی مقالات

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  1. A Bioinformatics Analysis of Common Genetic Variants in Nutrient-Related Genes Associated with Oral Cancer (Research Paper)

    Oral cancer is one of the most common malignancies of the head and neck region, ...Read more

  2. A Network Pharmacology Analysis of Synergistic Anti-Cancer Effects of Combined AXL and PARP Inhibition (Research Paper)

    Drug resistance remains a significant hurdle in cancer treatment. A promising st...Read more

  3. A Pan-Cancer Repurposing Framework for Saffron Bioactives Using Network-Centrality Filtering and cBioPortal Alteration Profiling (Research Paper)

    Natural product drug discovery increasingly emphasizes multi-target agents with ...Read more

  4. A Systematic Review of the Role of ABC Transporters in Breast Cancer Drug Resistance: Focus on ABCB1 (Review)

    Breast cancer ranks among the top causes of cancer-related fatalities in women g...Read more

  5. A Systems Pharmacology Approach to Food-Drug Interactions: Integrating Metabolism, Transport, and Genetics for Clinical Application (Review)

    Food-drug interactions (FDIs) are a critical area of pharmacotherapy with signif...Read more

  6. AI-Assisted Ancestry-Specific Pharmacogenomics: Bridging the Representation Gap in Precision Medicine (Review)

    The field of pharmacogenomics has long struggled with a critical limitation: the...Read more

  7. AI-Assisted Personalized Drug Dosing Using Genomic (Review)

    Precision dosing has emerged as a cornerstone of personalized medicine, aiming t...Read more

  8. AI-driven Multi-Omics Integration for Personalized Cancer Risk Prediction and Prevention (Review)

    Cancer continues to be one of the most significant global health challenges, imp...Read more

  9. AI-Driven Pharmacogenomics in Oncology: Overcoming Drug Resistance in Cancer Therapy (Review)

    Drug resistance is a critical challenge in cancer treatment, often leading to th...Read more

  10. AI-Enhanced Pharmacogenomics: Toward Clinically Actionable and Personalized Drug Therapy (Review)

    Inter-individual variability in drug response remains a major barrier to effecti...Read more

  11. Analysis of Methylation Status in Promoter Region of gamma- Globin Gene in Carrier and Affected Β-Thalassemia Patients with High Level of Fetal Hemoglobin in Comparison with Normal Individuals (Research Paper)

    Among the factors that may be associated with the re-expression of gamma-globing...Read more

  12. Antimetastatic activity of britannin, a sesquiterpene lactone isolated from Inula aucheriana against triple-negative breast cancer cells (Research Paper)

    Triple-negative breast cancer is the most aggressive form of breast tumors. Brit...Read more

  13. Artificial Intelligence and Large Language Models (LLMs) in Genomic Medicine, Bioinformatics, and Digital Health: Real-Time Monitoring of Patient Drug Response Using Big Data and Personalized Treatment (Review)

    With the remarkable advancements in artificial intelligence and the emergence of...Read more

  14. Artificial Intelligence Integration with CRISPR/Cas9: Toward Precision Genome Editing (Review)

    Clustered regularly interspaced short palindromic repeats (CRISPR) stores fragme...Read more

  15. Artificial Intelligence Platform for Personalized Drug Therapy Based on Patient Genetic Profiles: Integrating Pharmacogenomics and Genomics for Optimizing Treatment Response and Prevention (Review)

    With recent advancements in genomics and pharmacogenomics, precise personalized ...Read more

  16. Berberine Targets Kinase-Dense Regulatory Hubs in Pancreatic Ductal Adenocarcinoma: Insights from Network Pharmacology (Research Paper)

    Pancreatic ductal adenocarcinoma (PDAC) is an exceptionally lethal malignancy, w...Read more

  17. Beyond Single-Gene Pharmacogenetics: AI-Driven Polygenic and Epigenetic Dose Prediction for Cancer Therapeutics (Review)

    Conventional pharmacogenetics (PGx) based on variants of single genes (most nota...Read more

  18. Breast Cancer and Epigenetics, A Look at the Development and Progression (Review)

    Breast cancer is currently among the most commonly diagnosed cancers (1). The in...Read more

  19. Challenges in Nanomedicine and Personalized Medicine (Review)

    Nanomedicine and personalized medicine are both new to medical practice. As nano...Read more

  20. Choline Supplementation During Pregnancy: Impact on Fetal Brain Development (Review)

    Choline is an essential nutrient that plays a crucial role in the development of...Read more

  21. Computational Affinity Maturation of Ipilimumab: Site-directed Mutagenesis for Enhanced CTLA-4 Targeting (Research Paper)

    Monoclonal antibodies have transformed cancer therapy by targeting specific immu...Read more

  22. Converging Genomics and Multi-Modal AI to Advance Precision Medicine (Review)

    The past decade has witnessed a rapid evolution in precision medicine driven by ...Read more

  23. CVID vs SCID: How Flow Cytometry Reveals Critical T and B Cell Patterns (Review)

    Primary immunodeficiency disorders affect 1 in 1,200 people worldwide, with CVID...Read more

  24. Deep Learning for Single-Cell Genomics: Trends, Challenges, and Opportunities (Review)

    Recent progress in single-cell genomics has transformed our ability to interroga...Read more

  25. Effect of personalized diet on CYP450 gene expression and Drug Response: a new approach in precision medicine (Review)

    Pharmacogenetics, as an emerging branch in Precision Medicine, examines the effe...Read more

  26. Engineered Exosome-Based Cancer Vaccines: A Novel Strategy for Tumor Antigen Delivery and Immune Activation (Review)

    Cancer remains a major global health challenge, and despite advances in treatmen...Read more

  27. Epigenetic Modulation of Immune Checkpoints and Tumor Immune Signaling (Review)

    Cancer remains one of the leading causes of mortality worldwide, and immune evas...Read more

  28. Epigenetic Modulation of Tumor Suppressor and Oncogene Networks (Review)

    Aberrant epigenetic modifications play a central role in cancer initiation, prog...Read more

  29. Epigenetic Regulation of the PI3K/AKT/mTOR Pathway in Cancer: A Systematic Review of Mechanisms and Therapeutic Implications (Review)

    The PI3K/AKT/mTOR signaling pathway is one of the most frequently altered cascad...Read more

  30. Epigenetics and Cancer Signaling (Research Paper)

    Epigenetics is the study of how gene expression is regulated without changing th...Read more

  31. Ethical, Legal, and Regulatory Frameworks in Personalized Medicine and Pharmacogenetics (Review)

    As pharmacogenetics becomes integral to personalized medicine, concerns regardin...Read more

  32. Folate Intake Modulation of MTHFR C677T–Influenced Methotrexate Pharmacokinetics in Rheumatoid Arthritis: A Systematic Review (Review)

    Methotrexate (MTX) is the cornerstone of rheumatoid arthritis (RA) therapy, but ...Read more

  33. From Sequencing to Survival: Current Evidence and Gaps in Implementing Large-Scale Genomic Profiling for Advanced Cancer (Review)

    The integration of next-generation sequencing (NGS) into clinical oncology holds...Read more

  34. Genetic Polymorphisms of Cancer (Review)

    IntroductionGenetic polymorphisms, variations in DNA sequences within a populati...Read more

  35. Genotypic variants of the tetrahydrobiopterin (BH4) biosynthesis genes in patients with hyperphenylalaninemia from different regions of Iran (Research Paper)

    Hyperphenylalaninemia (HPA) is a metabolic disorder classified into phenylalanin...Read more

  36. Helicobacter pylori-induced inflammation's role in the development of an epigenetic field defect and its applicability as a measure of exposure and cancer risk. (Review)

    Several investigations have demonstrated that some infectious pathogens may caus...Read more

  37. High Performance, Low Trust: Bridging the Gap Between Algorithmic Potential and Clinical Reality in AI-Driven Diagnostics (Review)

    Artificial intelligence (AI) and machine learning (ML) are increasingly position...Read more

  38. Histone Deacetylase Inhibitor Sensitivity in EZH2-Mutant Diffuse Large B-Cell Lymphoma: A Systematic Review (Review)

    EZH2 gain-of-function mutations drive aberrant histone methylation and oncogenic...Read more

  39. HLA-B*57:01 Screening to Prevent Abacavir Hypersensitivity and Its Effect on Virologic Suppression in HIV-1 Infection: A Systematic Review (Review)

    Abacavir is a cornerstone of many antiretroviral regimens but carries a 5–8% r...Read more

  40. Impact of Nutritional Factors on Pharmacogenetic Profiles and Drug Response (Review)

    Pharmacogenetics tailors medications to the individual's enzymes, transporters, ...Read more

  41. In Silico Investigation of Ellagic Acid as a Potential HDAC1 Inhibitor in Breast Cancer (Research Paper)

    Because of its anticancer and antioxidant qualities, ellagic acid, a naturally o...Read more

  42. Integrating Pharmacogenomics with Patient Medication Experience: Ethical Considerations (Review)

    Personalization in medicine stands at the intersection of genetic insight, patie...Read more

  43. Investigation of EZH2 Inhibitors and Epigenetic Alterations in the Development of Tamoxifen Resistance in Breast Cancer (Research Paper)

    Breast cancer is the most common malignancy worldwide. Tamoxifen is the main hor...Read more

  44. Lung Cancer Epigenetic Changes and Signalling Interactions: Mechanisms, Biomarkers, and Treatment Prospects (Review)

    Introduction With a five-year survival rate of fewer than 20%, lung cancer is ...Read more

  45. Medical genetics (Review)

    IntroductionMedical genetics is a vital branch of medicine that examines how gen...Read more

  46. Meta-Analysis of Gene Expression: Functional Food Potential of Iodine-Biofortified Lettuce in Caco-2 Cancer Cells (Research Paper)

    While the iodization of salt remains the predominant strategy for producing iodi...Read more

  47. MGMT Promoter Methylation as a Predictor of Temozolomide Response and Survival in Glioblastoma: A Systematic Review (Review)

    O6-Methylguanine-DNA methyltransferase (MGMT) promoter methylation silences a ke...Read more

  48. MGMT Silencing and EGFR Amplification Synergy in Glioblastoma: Implications for Therapeutic Resistance (Review)

    Glioblastoma (GBM) represents the most aggressive primary brain tumor in adults,...Read more

  49. Microbiome-Based Therapy in Personalized Medicine for Alzheimer’s Disease (Review)

    Alzheimer’s disease (AD) is one of the most common neurodegenerative disorders...Read more

  50. MicroRNA Signaling in Cancer: Hidden Molecular Switches Controlling Tumor Growth (Review)

    Micro RNA molecules, though minuscule in size, wield enormous power over cancer ...Read more

  51. miR-21 Promoter Hypermethylation, PI3K/AKT Pathway Activation, and Prognosis in Hepatocellular Carcinoma: A Systematic Review (Review)

    Aberrant DNA methylation of microRNA promoters can dysregulate oncogenic signali...Read more

  52. Molecular Docking Analysis of Psammaplin A as a Potential MCL-1 Inhibitor in Colorectal Cancer (Research Paper)

    Psammaplin A, a bromotyrosine-derived natural product isolated from marine spong...Read more

  53. mRNA-Based Cancer Vaccines: A Novel Approach to Target Tumor-Specific Antigens Through Immune Activation (Review)

    In recent years, mRNA vaccine technology has emerged as a transformative platfor...Read more

  54. Nanotechnology-enabled pharmacogenomics: a revolution in cancer drug development (Review)

    The combination of pharmacogenomics and nanotechnology has created a highly adva...Read more

  55. Network-Pathway Integration Reveals Synergy Targets for Combination Therapy in Breast Cancer (Research Paper)

    Single-pathway therapies struggle against the modular, compensatory architecture...Read more

  56. New understanding of the reciprocal link between microRNA expression and epigenetic changes in human lung cancer (Review)

    Lung cancer remains a primary cause of cancer-related mortality globally. Despit...Read more

  57. Nutrigenomics and Pharmacogenetics: The Interplay Between Diet and Drug Metabolism (Review)

    Diet significantly affects the pharmacokinetics and pharmacodynamics of many dru...Read more

  58. Omega-3 Fatty Acid Supplementation and CYP2C19 Genotype Effects on Clopidogrel Efficacy: A Systematic Review (Review)

    Clopidogrel’s antiplatelet effect is highly dependent on CYP2C19‐mediated bi...Read more

  59. Optimization Strategies and Expanding Horizons of mRNA Vaccine Technology: Stability, Efficacy, and Beyond (Review)

    Messenger RNA (mRNA) vaccines have emerged as a groundbreaking platform in vacci...Read more

  60. Pharmacogenetic Insights into EGFR, ALK, and BRAF Mutations and Their Role in Tyrosine Kinase Inhibitor Response (Review)

    Tyrosine kinase inhibitors (TKIs) have revolutionized the field of targeted canc...Read more

  61. Pharmacogenetic study of drugs used by patients with amyotrophic lateral sclerosis (ALS) (Research Paper)

    Introduction: Amyotrophic lateral sclerosis (ALS) is a progressive and disabling...Read more

  62. Pharmacogenetics of CYP450: A Pathway to Tailored Drug Therapy (Review)

    According to pharmacogenomics, the identification of genetic variations that imp...Read more

  63. Pharmacogenetics of Opioid Analgesics: Toward Safer Pain Management (Review)

    Opioid analgesics remain a mainstay in the management of moderate to severe pain...Read more

  64. Pharmacogenomics-guided drug personalization in psychiatry: leveraging genetic biomarkers for treatment of depression and ADHD (Review)

    Mood disorders, including major depressive disorder (MDD), and neurodevelopmenta...Read more

  65. Pharmacogenomics-Guided Therapy Selection in Oncology: 2024–2025 Evidence and Implementation (Review)

    The integration of advanced computational approaches with molecular profiling ha...Read more

  66. Pharmacological Targeting of the Cancer Epigenome: Recent Trends and Challenges (Review)

    Epigenetics refers to the study of reversible heritable changes in gene expressi...Read more

  67. PI3K/AKT/mTOR signaling pathway and the influence of miRNAs in cancer (Review)

    Cancer development is driven by genomic mutations that promote abnormal prolifer...Read more

  68. Professor (Research Paper)

    Vancomycin a commonly administered antibiotic for various Gram-positive infectio...Read more

  69. Recent Progress in Glioblastoma Targeted Therapy via Smart Nanoparticle Delivery Systems (Review)

    The burgeoning field of nanobiomedicine, by integrating nanotechnology with biom...Read more

  70. Role of mitochondrial epigenetics in tumoral drug resistance (Review)

    Drug resistance remains a major challenge in cancer therapy, though the underlyi...Read more

  71. Safety and Long Term Effectiveness of Psychotropic and Stimulant Medications in Children and Adolescents with ADHD: A Population Based Multi Provincial Cohort Study and Systematic Review (Review)

    Background: Attention-Deficit/Hyperactivity Disorder (ADHD) affects 5–7% of ...Read more

  72. Synergistic Effects of Engineered Green Environments and Advanced Gene Editing in Promoting Retinal Regeneration and Repair (Review)

    This study pioneers an integrated "engineered synergy" approach, mergi...Read more

  73. Synthetic Epigenetic Engineering of Extremophilic Bacteria: Prospects for Biotechnological and Space Applications (Review)

    Extremophilic bacteria possess extraordinary resilience to environmental stresso...Read more

  74. Targeted Lipid-Based Nanoparticles for Non-Surgical Management of Advanced Lung and Pancreatic Cancers: A Smart Drug Delivery Approach (Review)

    The inefficiencies of classical non-surgical methods for treating conditions suc...Read more

  75. The Role of Bioresonance in Modulating Epigenetics and Cancer Signaling: An Innovative Approach Based on Molecular Evidence and Resonance Technologies (Review)

    In recent years, advances in medical science and emerging technologies have faci...Read more

  76. The Role of Epigenetics and Signaling Pathways in Liver Cancer: A Review of Mechanisms and Therapeutic Applications (Review)

    Liver cancer (particularly hepatocellular carcinoma, HCC) is among the most leth...Read more

  77. The Role of RASSF1A Gene Methylation in Lung Cancer and Prediction of Response to Targeted Therapies: A Systematic Review (Review)

    Lung cancer, especially non-small cell lung cancer (NSCLC), is the deadliest can...Read more

  78. Trimethylbenzoyl Diphenylphosphine Oxide (TPO) in Gel Nail Polishes: A Comprehensive Review (Review)

    Trimethylbenzoyl Diphenylphosphine Oxide (TPO) is a photoinitiator extensively u...Read more

  79. Unlocking Nature's Arsenal: The Expanding Therapeutic Role of Berberine in Combating Lung Cancer (Review)

    Lung cancer remains the most formidable adversary in the field of oncology, dist...Read more

  80. Utilizing Personalized Medicine to Diagnose and Treat Helicobacter pylori: Targeted Prevention and Treatment Strategies (Review)

    Helicobacter pylori (H. pylori) is a Gram-negative bacterium implicated in the p...Read more

  81. Vitamin D Pharmacogenomics in Cancer: Genetic and Metabolic Insights for Personalized Therapy (Review)

    Vitamin D, a hormone similar to steroids, can be produced within the body and is...Read more

  82. Why Pharmacogenomics Predicts Drug Response with 90% More Accuracy: New Research Findings (Review)

    Did you know that adverse drug reactions cause over 100,000 deaths annually in t...Read more

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